Preparation of solutions of compounds insoluble or sparingly soluble in water



Patented June 14, 1927.

WALTER IVIINNICH, O13 MONTREUX, SWITZERLAND, ASSIG'NOR TO SOCIETY OF CHEML GAL INDUSTRY IN BASLE, F BASEL, SVTITZERLAND.

PREPARATION OF SOLUTIONS OF COMPOUNDS INSOL'UBLE OE SPAEI'NGLY SOLUBLE I1\T WATER.

.No Drawing. Application filed November 10, 19%, Serial No. 749,046, and in Switzerland November 19,

The invention relates to the preparation of solutions of compounds insoluble or sparingly soluble in Water byusiug phenylacetylene as a solvent.

5 I have found that phenylacetylene is capable in a high degree of dissolving certain therapeutic compounds, especially camphor or mixtures of camphor With lipoids, such. as for instance cholesterin or esters of saturated or unsaturated organic acids with cholesterin, and the like, and that the solutions thus obtained may be injected subcutaneously or intramuscularly Without causing any irritation. The solutions may also be employed for per-cutaneous use according to the properties of the dissolved compounds.

The solutions obtained according to the present invention are thus useful for a large variety of purposes, particularly in human or veterinary medicine.

Example 1.

50 parts of phenylacetylene are introduced into 50 parts of camphor. The eamphor readily dissolves completely. The mobile solution thus obtained is filtered, if necessary, and may be employed for injections without any further treatment.

Err/ample 2.

Analogous solutions may be obtained with 50 parts of phenylacetylene, 50 parts of camphor and from 610 parts of the cholesterol other of phenylpropiolic acid or crotonic acid, 'or other unsaturated organic acids. Of course, instead of a cholesterin ether in this example cholesterin itself or another lipeid may be employed.

hat I claim is: i

1. As an article of manufacture, solutions of camphor 'in phenylacetylene.

2. As an article ofmanufacture solutions of camphor and lipoids in phenylacetylene.

8. As an article of'manufacture, solutions of camphor and cholesterol in phenylacetylene.

. 4-. As an article of manufacture, solutions of cainphor and esters of cholesterol. in phenylacetylene.

5. As an article of manufacture, solutions of. caniphor and unsaturated acid esters of cholesterol in phenylacetylene.

In Witness whereof I have hereunto signed my name this 27 day of October 1924.

VJALTER MINNICH. 

